Status:
COMPLETED
Brain Markers of Suicide Risk and Psychological Pain in Elderly Depressed Patients
Lead Sponsor:
Centre Hospitalier Universitaire de Nīmes
Conditions:
Depressive Disorder
Suicide, Attempted
Eligibility:
All Genders
60+ years
Brief Summary
The main objective of this study is to show MRI functional and structural differences between depressed elderly patients with a history of attempted suicide compared to depressed elderly patients with...
Eligibility Criteria
Inclusion
- The patient must have given their free and informed consent and signed the consent form
- be a member or beneficiary of a health insurance plan
- aged 60 years-old or more
- must be right-handed
- with a diagnosis of a current major depressive episode of moderate to severe severity according to diagnostic criteria.
- with or without a personal history of attempted suicide during life
- hospitalized or followed by a consultant in the department of Psychiatry of Nîmes University Hospital or in the Sophoras private clinic
Exclusion
- The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study
- under safeguard of justice
- refuses to sign the consent
- It is impossible to give the subject informed information
- Current psychotic symptoms.
- Bipolar disorder.
- The subject presents an acute somatic decompensation incompatible with the realization of this study.
- The patient presents a mental confusion or a known Mini Mental State Examination score \<24.
- Central neurological disease known in particular degenerative pathology, severe cranial trauma and severe cerebrovascular disease.
- Schizophrenia and other known psychotic disorders.
- Electroconvulsive therapy in the 12 months prior to study
- Inability to perform neuropsychological tests because of a language problem, poor understanding, a major tremor, inability to sit still, a major sight problem that cannot be corrected, or other severe cognitive impairment
- Contra-indication to magnetic resonance imaging (MRI): ferromagnetic implant in the body, piercing, claustrophobia, inability to remain elongated for 45 minutes.
Key Trial Info
Start Date :
August 18 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 13 2019
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03287986
Start Date
August 18 2017
End Date
December 13 2019
Last Update
March 9 2020
Active Locations (1)
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1
CHU Nimes
Nîmes, France, 30029