Status:
RECRUITING
Influence of Brain Oscillation-Dependent TMS on Motor Function
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Healthy
Stroke
Eligibility:
All Genders
18+ years
Brief Summary
Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move the...
Detailed Description
Study Description: We will study if corticospinal excitability, intracortical inhibition and intracortical facilitation vary across different sensorimotor alpha and beta electroencephalography (EEG) ...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Healthy younger adults:
- Ages 18 years to less than 50 years. (18 to 49)
- Willingness/ability to provide informed consent.
- Ability to induce a motor evoked potential in the muscle target of the upper extremity, as evaluated during the TMS Screening.
- Healthy older adults:
- Age 50 and over
- Willingness/ability to provide informed consent.
- Ability to induce a motor evoked potential in the muscle target of the upper extremity, as evaluated during the TMS Screening.
- Stroke patients:
- Age 18 and over.
- Unilateral or bilateral upper limb paresis with the ability to voluntarily contract a finger, hand, wrist, or elbow muscle in the affected arm(s).
- Stroke onset \> 6 months prior to participation.
- Intact M1 sufficient to induce motor evoked potentials in the affected upper extremity following ipsilesional TMS, as evaluated during the TMS Screening.
- Willingness/ability to provide informed consent.
- If the investigator feels the individual s capacity to provide informed consent is questionable, the NIH Human Subjects Protection Unit (HSPU) will be requested to determine the individual s ability to consent.
- EXCLUSION CRITERIA:
- Healthy younger and older adults:
- Presence of severe neurological or medical disorder (e.g., Parkinson s disease or multiple sclerosis).
- History of seizures.
- Chronic use of antipsychotic drugs (e.g., chlorpromazine or clozapine), tri-cyclic or other anti-depressants, benzodiazepines, or prescription stimulants.
- TMS contraindications, such as:
- Pacemaker, implanted pump, stimulator, cochlear implant, or metal objects inside the eye or skull.
- Diagnosed severe hearing loss.
- Current pregnancy.
- Staff from our section.
- Stroke patients:
- Presence of severe neurological or medical disorder, other than stroke (e.g., Parkinson s disease or multiple sclerosis).
- History of brainstem stroke.
- History of seizures.
- Chronic use of antipsychotic drugs (e.g., chlorpromazine or clozapine), benzodiazepines, or prescription stimulants.
- TMS contraindications, such as:
- Pacemaker, implanted pump, stimulator, cochlear implant, or metal objects inside
- the eye or skull.
- --Diagnosed severe hearing loss.
- Current pregnancy.
- Staff from our section.
Exclusion
Key Trial Info
Start Date :
September 11 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 31 2026
Estimated Enrollment :
114 Patients enrolled
Trial Details
Trial ID
NCT03288220
Start Date
September 11 2018
End Date
March 31 2026
Last Update
October 24 2025
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892