Status:
UNKNOWN
Management and Outcomes of Anti-thrombotic Medication Use in Thrombocytopenia
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Hematologic Neoplasms
Thrombocytopenia
Eligibility:
All Genders
18+ years
Brief Summary
Background: Antithrombotic therapy in the context of treatment related thrombocytopenia (i.e. low levels of platelets) is not uncommon. Guidelines are based upon a paucity of retrospective data and fo...
Detailed Description
* Thrombocyte-level cohorts Patients will be divided into two groups based on the platelet level at study index . 1. Thrombocytopenic Cohort: Patients with morning platelet count below 50\*109/L at...
Eligibility Criteria
Inclusion
- Any hematological malignancy with or without active treatment (including autologous or allogeneic stem cell transplantation), irrespective of the treatment line and disease status.
- Disease-related and/or current/predicted treatment-related thrombocytopenia (\<50 X 109/L) of any duration.
- Current antiplatelet and/or anticoagulant treatment of any duration and for any indication. This treatment may have been started before or after diagnosis of the hematological malignancy and thrombocytopenia.
- "Current" refers to the time when the current thrombocytopenia, or risk thereof (i.e. "predicted"), was first identified (even if the treatment is subsequently stopped)
Exclusion
- Previous thrombocytopenia (\<50 X 109/L) while using the current antithrombotic regimen.
- Current diagnosis of heparin induced thrombocytopenia (HIT) or thrombotic thrombocytopenia purpura (TTP)
Key Trial Info
Start Date :
March 20 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2021
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT03288441
Start Date
March 20 2018
End Date
December 31 2021
Last Update
September 17 2020
Active Locations (21)
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1
Oregon Health & Science University Hospital
Portland, Oregon, United States, 97239
2
Rambam Health Care Campus
Haifa, Israel
3
Meir Medical Center
Kfar Saba, Israel, 4428164
4
Rabin Medical Center
Petah Tikva, Israel