Status:
UNKNOWN
Antiarrhythmic and Cardioprotective Effects of Atorvastatin Versus Magnesium Sulfate in Cardiac Valve Replacement Surgery
Lead Sponsor:
Assiut University
Conditions:
Arrhythmias
Eligibility:
All Genders
18-50 years
Phase:
PHASE4
Brief Summary
This study aims to compare the antiarrhythmic and cardioprotective effects of Atorvastatin versus Magnesium Sulfate after Cardiac valve Replacement Surgery
Detailed Description
Arrhythmia is a common complication after cardiac valve surgery. Postoperative atrial fibrillation (POAF) is the most common type of arrhythmia after cardiac surgery. It has different leading causes, ...
Eligibility Criteria
Inclusion
- Patients undergoing isolated valvular replacement surgery.
- Preoperative rhythm: Sinus rhythm.
- Preoperative troponin I \< 0.01 ng/mL.
- Normal lipid profile.
- White blood cells (4-11 X 103/mm3).
- Preoperative C-reactive protein \< 3 mg/L.
Exclusion
- History of atrial fibrillation.
- Any degree of heart block or patients with implanted pacemaker.
- Prior use of Antiarrhythmic drugs.
- Preoperative lipid lowering therapy (e.g statins) during the last 3 months.
- Previous treatment with any type of magnesium containing supplementation (the week before the intervention).
- Underlying heart failure or Left ventricular ejection fraction \< 0.3.
- Previous myocardial infarction.
- Diabetes or other metabolic disorders.
- Renal diseases.
- Hepatic dysfunction.
- Underlying thyroid problems (hypo/hyperthyroidism).
- Underlying inflammatory disease (active or controlled)
- Immunosuppressive and anti-inflammatory medications for the treatment of coexisting conditions.
- Psychological disorders,
- Emergency cardiac surgery
Key Trial Info
Start Date :
September 24 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2018
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT03289429
Start Date
September 24 2017
End Date
February 1 2018
Last Update
February 13 2018
Active Locations (1)
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1
Assiut University
Asyut, Egypt, 71515