Status:
COMPLETED
The Combination Effect of Platelet-rich Plasma and Hyaluronic Acid for Knee Osteoarthritis
Lead Sponsor:
Tri-Service General Hospital
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
50-75 years
Phase:
NA
Brief Summary
Although platelet rich plasma (PRP) and Hyaluronic acid (HA) are beneficial for osteoarthritis of knee (OA knee), the combined effect of PRP with HA was not clear so far. Hence, investigator assess a ...
Detailed Description
Patients with single or bilateral OA knee will be enrolled and randomized into intervention and control group. One dose of PRP is applied into both groups. One week later, one dose of HA is injected i...
Eligibility Criteria
Inclusion
- Age between 50 to 75 y/o.
- Alert consciousness
- Symptom of knee osteoarthritis persist at least 6 months and stage I to III scored by Ahlbäck grading system
- The pain score measured by VAS at least 4 points
Exclusion
- Has received hyaluronic acid, PRP or steroid injection within 6 months
- Has received NSAIDs or steroid within one week
- Tumor or metastasis surrounding the knee joint
- Has received total knee replacement, major surgery in knee, rheumatoid arthritis
- Patient who cant tolerance the balance test.
- Thrombocytopenia or coagulopathy
Key Trial Info
Start Date :
January 10 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2021
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT03290365
Start Date
January 10 2018
End Date
July 1 2021
Last Update
July 13 2021
Active Locations (1)
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1
Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital
Taipei, Neihu District, Taiwan, 886