Status:
COMPLETED
Evaluation to Assess Safety and Tolerability of DM199 in Subjects With Acute Ischemic Stroke
Lead Sponsor:
DiaMedica Therapeutics Inc
Conditions:
Acute Ischemic Stroke
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This is a Phase II study to assess the safety and tolerability of DM199 in acute ischemic stroke patients. The study will be randomized, placebo controlled at multiple centers.
Eligibility Criteria
Inclusion
- Subject is \>/= 18 years of age
- Subject has been diagnosed with acute ischemic stroke with onset ≤ 24 hours from enrollment.
- Subject has NIH stroke score (NIHSS) ≥ 6 and ≤ 25.
- Subject or legally authorized representative is willing and able to sign written informed consent.
Exclusion
- Subject is currently prescribed angiotensin-converting-enzyme inhibitors (ACEi) and is unable or unwilling to convert to another antihypertensive pharmacological treatment during the active treatment period (+5 days) of the study.
- Subject has a history of significant allergic diathesis such as urticaria, angioedema or anaphylaxis.
- Subjects with current malignancy or active malignancy ≤ 3 years prior to enrollment except basal cell or squamous cell carcinoma of the skin or in situ cervical cancer that has undergone potentially curative therapy and at least six months have elapsed since the procedure.
- Subject has a history of clinically significant acute bacterial, viral, or fungal systemic infections in the last four weeks prior to enrollment.
- Subject has clinical or laboratory evidence of an active infection at the time of enrollment.
- Subject has known alpha 1-antitrypsin deficiency (α1-antitrypsin deficiency).
- Subject has a known diagnosis of human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or anti-hepatitis C virus (Anti-HCV) at screening.
- Subject is pregnant or nursing.
- Subject is male or female of childbearing potential, is participating in heterosexual sexual activity that could lead to pregnancy, and is unable or unwilling to practice medically effective contraception during the study.
- Subject is participating in any other investigational device or other drug study ≤ 4 weeks or 5 half-lives of the investigational product, whichever is longer.
- Subject does not have sufficient venous access for infusion of study treatment or blood sampling.
- In the opinion of the Investigator, subject is unlikely to be followed for the duration of t the study.
- Subject is unable or unwilling to comply with protocol requirements, including assessments, tests, and follow-up visits.
- Subject has any other medical condition which in the opinion of the Investigator will make participation medically unsafe or interfere with the study results.
- Pre-stroke Modified Rankin Scale ≥4
Key Trial Info
Start Date :
January 19 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 23 2020
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT03290560
Start Date
January 19 2018
End Date
January 23 2020
Last Update
March 31 2022
Active Locations (12)
Enter a location and click search to find clinical trials sorted by distance.
1
Lismore Base Hospital
Lismore, New South Wales, Australia
2
Liverpool Hospital
Liverpool, New South Wales, Australia
3
John Hunter Hospital
New Lambton Heights, New South Wales, Australia
4
Royal Brisbane and Women's Hospital
Herston, Queensland, Australia