Status:
COMPLETED
Determining the Impact of Shunting and CerebroVascular Reactivity on 7T MRI (DISCoVeR 7T MRI)
Lead Sponsor:
University of Pennsylvania
Conditions:
Cognitive Impairment
Eligibility:
All Genders
60+ years
Brief Summary
The purpose of this study is to use transcanial doppler (TCD) ultrasound to look for possible risk factors for ischemic brain injury. We will perform contrast TCD with agitated saline contrast to iden...
Eligibility Criteria
Inclusion
- Males and females ≥ 60 years of age.
- Fluent in English.
- Part of the NACC longitudinal cohort (Protocol #: 068200) of the PMC/ADCC with consensus conference designation of cognitively normal, Mild Cognitive Impairment, or probable/possible Alzheimer's disease.
- Has consented to participate in the ADCC high-resolution MRI sub-study.
- NACC longitudinal visit must be within 6 months of the TCD study and brain MRI study.
- Women: post-menopausal or surgically sterile.
- Willing and able to complete all required study procedures.
- Completed 6 grades of education.
- Geriatric Depression scale less than 6 (assessed within 6 months at the NACC longitudinal visit).
Exclusion
- Prior clinically symptomatic ischemic or hemorrhagic stroke.
- Inability to tolerate or contraindication to TCD study in the opinion of an investigator or treating physician.
- Any medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study.
Key Trial Info
Start Date :
October 26 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2023
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT03291340
Start Date
October 26 2017
End Date
October 1 2023
Last Update
December 5 2024
Active Locations (1)
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1
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104