Status:
COMPLETED
Efficacy of Intralesional Injection of Platelet Rich Plasma in the Treatment of Patients With Erosive Oral Lichen Planus
Lead Sponsor:
Cairo University
Conditions:
Erosive Oral Lichen Planus
Eligibility:
All Genders
Phase:
PHASE2
Brief Summary
After signing the informed consent, the participant will be allocated to either intervention or control group, then each participant in the intervention group will receive intralesional injections of ...
Eligibility Criteria
Inclusion
- Patients presenting with a clinical picture that assumes the diagnosis of erosive oral lichen planus (bilateral, more or less symmetrical erosive lesions with lacelike network of slightly raised gray white lesions (reticular pattern), and a histological findings that confirms the diagnosis (liquefaction degeneration of the basal cell layer with irregular-saw teeth like rete pegs.
Exclusion
- Systemic disorders such as hematological diseases, severe cardiovascular diseases, treatment with any drugs that could cause Lichenoid reaction.
- Pregnancy or active breastfeeding
- Patients who had lesion/lesions with dysplasia
- Patients who received topical treatment for Oral Lichen planus in the last 2 weeks (Lee et al., 2013) or systemic treatment for OLP in the past 3 months.
- Platelet count \< 150,000/mm3; Hgb \< 11 g/dl.
- Immunosuppressed patients
- Patients receiving therapy with anticoagulants and use of non-steroidal anti-inflammatory drugs in the 5 days before taking the blood sample.
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2021
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03293368
Start Date
January 1 2018
End Date
January 1 2021
Last Update
February 9 2023
Active Locations (1)
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1
Faculty of Dentistry
Cairo, Egypt