Status:
TERMINATED
Characterization of Regulatory T Lymphocytes in the Synovial Fluid of Patients Affected by Rheumatoid Arthritis.
Lead Sponsor:
University Hospital, Montpellier
Conditions:
Rheumatoid Arthritis
Swelling Joint
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
In rheumatoid arthritis (RA) the clinical response to anti-TNFα is related to an increase in the number or in the function of Treg lymphocytes in the peripheral blood of patients. This observation sug...
Detailed Description
Transverse observational, monocentric exploratory study based on physiopathological evaluation Phase of identification/characterization of biomarkers. In a second phase, investigators might also consi...
Eligibility Criteria
Inclusion
- 18 to 65 years old
- patients with rheumatoid arthritis according to 2010 ACR/EULAR criteria
- Patients with swelling joint suffering from an episode of acute articular flare link to RA and that requires an aspiration of joint fluid (RA with less than 3 months of evolution confirmed by clinical examination and/or joint ultrasound)
- Patients who agreed to participate to this study and signs the informed consent form
Exclusion
- Septic arthritis confirmed by microbiological analysis of synovial fluid
- Osteoarthritis of the reference joint confirmed by X-ray
- Contraindication for joint aspiration: Platelets \< 50 000/mm3, Prothrombin time \<70%, Partial Thromboplastin Time Blood Test-PTT \> 1,5 times compare to the control sample, anticoagulant therapy
- Biotherapy (including (anti-TNF-α), corticosteroid (orally, intravenously or intra-articulary) or others immunosuppressive drug (current treatment or treatment within 3 months before joint aspiration).
- Pregnancy, mother in the post natal period or breastfeeding.
Key Trial Info
Start Date :
October 17 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 27 2021
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT03293667
Start Date
October 17 2017
End Date
July 27 2021
Last Update
September 30 2025
Active Locations (1)
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1
Lapeyronie Hospital
Montpellier, France, 34295