Status:
TERMINATED
Opioid Induced Loss of Local Anesthetic Potency in Patients Undergoing Total Knee Arthroplasty
Lead Sponsor:
University of Pittsburgh
Conditions:
Opioid Tolerance, Opioid Naive, Opioid Exposure
Eligibility:
All Genders
18-80 years
Brief Summary
Peripheral nerve blocks with local anesthetics (LAs) have become an integral part of postoperative pain management particularly for patients undergoing major limb procedures such as such as Total Knee...
Detailed Description
3 groups of patients will be included in this prospective study: opioid naïve, those using opioids at the time of surgery (opioid tolerant), and those with a history of opioid use, but who are not cur...
Eligibility Criteria
Inclusion
- American Society of Anesthesiologists Classification 1,2 and 3;
- Age between 18-80;
- Both males and females of all races
- Receive total knee arthroplasty (TKA)
- Agree to receive peripheral nerve blocks for postoperative pain control
- Participants of the study will belong to one of the three groups: opioid naive, opioid history (those with a history of opioid use, but who are not currently on opioids) and opioid tolerant (those using opioids at the time of surgery)
Exclusion
- Intolerance and/or known allergy to opioids and/or LAs;
- TKA due to trauma;
- Use of general anesthesia for the operation
Key Trial Info
Start Date :
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2017
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT03294174
End Date
June 1 2017
Last Update
November 9 2018
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15206