Status:
COMPLETED
Predicting Sites of Tumour Progression in the Invasive Margin of Glioblastomas (PRaM-GBM Study)
Lead Sponsor:
CCTU- Cancer Theme
Collaborating Sponsors:
Cambridge University Hospitals NHS Foundation Trust
Cancer Research UK
Conditions:
High Grade Glioma
Eligibility:
All Genders
16+ years
Brief Summary
Brain tumours are the leading cause of cancer deaths in children, men under the age of 45 and women under the age of 25. Glioblastoma is the most common and most malignant primary tumour. The predomin...
Detailed Description
This is a multicentre, prospective longitudinal observational cohort study in patients with high grade glioma, who have surgery planned to remove \>90% of the tumour, and subsequent radical radiothera...
Eligibility Criteria
Inclusion
- Have given written informed consent to participate
- Assessed by a neuroscience MDT to have a high grade glioma on imaging, OR if in the opinion of the CI, with guidance from the local PI that all relevant and appropriate members of a multidisciplinary team agree a high grade glioma diagnosis;
- Considered suitable for radical radiotherapy (60 Gy) with concomitant chemotherapy (Stupp Regime);
- WHO PS 0 or 1 (see Appendix 3);
- Age ≥16;
- Patient suitable for tumour resection where the treating neurosurgeon feels that \>90% of the enhancing tumour will be resected;
Exclusion
- Patients who are participating in trials involving investigational treatments
- Patients who are unsuitable for a contrast-enhanced MRI will be excluded. Such clinical problems include, but are not limited to:
- MR unsafe metallic implants;
- Claustrophobia;
- Allergy to gadolinium contrast agent;
- History of severe renal impairment.
- Patients unable to provide written informed consent
- PET sub-study only: Pregnant women
Key Trial Info
Start Date :
March 2 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 11 2024
Estimated Enrollment :
147 Patients enrolled
Trial Details
Trial ID
NCT03294434
Start Date
March 2 2017
End Date
July 11 2024
Last Update
September 27 2024
Active Locations (1)
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1
Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom, CB2 0QQ