Status:
UNKNOWN
Towards Neurobiology-based Diagnosis and Treatment of Affective Disorders
Lead Sponsor:
Peking University
Conditions:
Affective Disorder
Eligibility:
All Genders
18-55 years
Brief Summary
The project is a multi-center, prospective cohort study. The study's total targeted enrollment is 400 first-episode patients with major depressive disorder (MDD) and 400 healthy controls.
Detailed Description
Four hundred patients with a primary diagnosis of depression and HAMD-17 scores ≥14 at baseline visit are to be assigned to one of the second-generation antidepressant drugs, including escitalopram, d...
Eligibility Criteria
Inclusion
- 1\. Patients with depression
- The inclusion criteria for depressed patients were: male or female outpatients aged between 18 and 55 years old
- Currently in acute depressive episode
- Total HAMD-17 score≥14 at baseline visit.
- The diagnosis of depression was confirmed by a trained psychiatrists using the Mini-International Neuropsychiatric Interview (MINI).
- The patients participating in imaging scans should additionally satisfy: not taking psychiatric drugs within last two weeks (except for benzodiazepine) or fluoxetine last one month
- Not receiving ECT within last 6 months.
Exclusion
- Unable to complete the questionnaire and psychological assessment independently
- Significant cognitive impairments determined by system mental examination and inability to sign an informed consent form
- Past or presently suffering from other psychiatric disorders, alcohol and drug dependence
- Suffering from major physical diseases, such as cardiovascular and cerebrovascular diseases, respiratory diseases, kidney disease, cancer and so on; personality disorder
- Intellectual disabilities
- Suicidal behavior
- Being participating in other studies.
Key Trial Info
Start Date :
January 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2022
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT03294525
Start Date
January 1 2016
End Date
August 1 2022
Last Update
August 30 2021
Active Locations (1)
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1
Institute of mental health, Peking University
Beijing, Beijing Municipality, China, 100191