Status:
RECRUITING
Morphologic Evolution and Remodeling of Intracranial Atherosclerosis: A Longitudinal Study by 3D-rotational Angiography
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Ischemic Stroke
Atheroscleroses, Cerebral
Eligibility:
All Genders
18-80 years
Brief Summary
This study is to elucidate the morphologic evolution and remodeling of ICAD under stringent control of cardiovascular risk factors.
Detailed Description
The investigator has conducted extensive research on ICAD by transcranial Doppler ultrasound, CT angiography and perfusion studies, magnetic resonance imaging (MRI) and digital subtraction angiography...
Eligibility Criteria
Inclusion
- Patient is 30 to 85 years of age, inclusive.
- Patients who have an acute infarct in diffusion-weighted MRI compatible with artery-to-artery thrombo-embolism and a relevant intracranial atherosclerotic stenosis ≥60%.
- Patient who has no contra-indication for the proposed imaging tests.
- Patient understands the purpose and requirements of the study, and has provided an informed consent.
Exclusion
- Patient with any of the following conditions would be excluded:
- Stroke etiology uncertain or unrelated to intracranial atherosclerosis, such as cardioembolism, Moyamoya disease, small vessel disease or primary angiitis of CNS.
- A tandem stenosis \>50% at extra-cranial internal carotid artery.
- Bleeding propensity: active peptic ulcer disease, major systemic hemorrhage within 30 days, thrombocytopenia (platelets \<100 x 109/L), coagulopathy (INR \>1.5).
- A medical condition that would not allow the patient to adhere to the protocol or complete the study.
Key Trial Info
Start Date :
August 22 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT03295773
Start Date
August 22 2016
End Date
June 30 2026
Last Update
February 12 2025
Active Locations (1)
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1
Chinese University of Hong Kong
Hong Kong, Hong Kong