Status:
COMPLETED
Effects of Positive End-expiratory Pressure on Intracranial Pressure in Patients With Severe Traumatic Brain Injury
Lead Sponsor:
Hongpeng Li
Conditions:
Traumatic Brain Injury
Mechanical Ventilation Complication
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The impact of PEEP on ICP was dependent on the difference between elevated CVP levels and baseline ICP levels. ICP would increase once elevated CVP through PEEP adjustment exceeds the baseline ICP.
Detailed Description
all patients were exposed to incremental PEEP levels of 0, 5, 10, and 15cmH2O with 100% of FiO2. The measurements were done bedside on stabilized hemodynamics and intracranial pressure. The measuremen...
Eligibility Criteria
Inclusion
- All patients diagnosed with sTBI (GCS≤8) and applied with MV were initially included.
Exclusion
- Brain death
- Younger than 18 or older than 80 years
- Pregnancy
- Hemodynamic instability：for example heart rate \>120 bpm or CPP \<60 mmHg
- Bulbous lung or pneumothorax
- Myocardial infarction
- Refusal of consent
Key Trial Info
Start Date :
August 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2017
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT03296293
Start Date
August 1 2016
End Date
August 1 2017
Last Update
October 2 2017
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