Status:
ACTIVE_NOT_RECRUITING
Genetic Mutational Analysis of Saliva or Buccal Mucosa Samples From Patients With Embryonal or Alveolar Rhabdomyosarcoma
Lead Sponsor:
Children's Oncology Group
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Alveolar Rhabdomyosarcoma
Embryonal Rhabdomyosarcoma
Eligibility:
All Genders
Up to 50 years
Brief Summary
This research trial studies genetic mutations in saliva or buccal mucosa samples from patients with embryonal or alveolar rhabdomyosarcoma. Identifying gene mutations may help doctors learn about the ...
Detailed Description
PRIMARY OBJECTIVES: I. To identify novel recurrent de novo germline mutations among rhabdomyosarcoma (RMS) case-parent trios. II. To identify the frequency of de novo germline mutations in cancer pr...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- The patient must be enrolled on ACCRN07 and/or APEC14B1 and registered with COG by a North American member institution
- The patient must have a diagnosis of embryonal rhabdomyosarcoma or alveolar rhabdomyosarcoma
- The patient must be diagnosed with rhabdomyosarcoma between January 1, 2012 and November 30, 2019
- Concomitant treatment on a therapeutic trial is not required
- The patient must have at least one biological parent alive and willing to participate
- All questionnaire respondents must understand English or Spanish
- All patients and/or their parents or legal guardians must sign a written informed consent
- All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met
Exclusion
Key Trial Info
Start Date :
October 23 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
900 Patients enrolled
Trial Details
Trial ID
NCT03296371
Start Date
October 23 2017
End Date
December 31 2025
Last Update
January 30 2025
Active Locations (1)
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1
Childrens Oncology Group
Philadelphia, Pennsylvania, United States, 19104