Status:
UNKNOWN
Non-invasive Ventilation vs. Standard Therapy for Children Hospitalized With an Acute Exacerbation of Asthma
Lead Sponsor:
University of British Columbia
Collaborating Sponsors:
Post Graduate Institute of Medical Education and Research, Chandigarh
Conditions:
Asthma Acute
Asthma in Children
Eligibility:
All Genders
2-18 years
Phase:
NA
Brief Summary
Acute asthma produces greatly increased work of breathing and increased oxygen requirement secondary to bronchial narrowing and airway obstruction by inflammatory secretions. There is growing evidence...
Detailed Description
The aim of the study is to determine if the use of NIV, for children admitted to hospital with an acute exacerbation of asthma, reduces their work of breathing, need for adjunctive medication, length ...
Eligibility Criteria
Inclusion
- 2-18 years old
- Clinical diagnosis of acute asthma exacerbation (respiratory rate greater than WHO's age-dependent criteria, a history of similar previous episodes and wheezing heard on auscultation by an experienced physician)
- PRAM score of 8 or more after 2 hours post-steroid administration
- Parents willing and able to sign consent
- Children over the age of 6 willing to provide assent
Exclusion
- Clinical suspicion of bacterial pneumonia: focal crackles or bronchial breathing, and/or major chest x-ray findings.
- Impending respiratory failure at presentation requiring direct PICU admission
- Any contraindication to BiPAP use including altered mental status, recent bowel surgery, intractable vomiting, inability to protect airway, pneumothorax.
- Receiving maintenance dose of oral steroid at time of hospital admission
- History of serious unrelated illness such as congenital heart disease or bronchopulmonary dysplasia.
Key Trial Info
Start Date :
June 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2018
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03296579
Start Date
June 1 2018
End Date
December 1 2018
Last Update
May 2 2018
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