Status:
COMPLETED
Paracetamol Metabolism Research in Postoperative Hepatic Surgery
Lead Sponsor:
University Hospital, Lille
Conditions:
Paracetamol Causing Adverse Effects in Therapeutic Use
Hepatic Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The main objective of this study was to evaluate the 5-day kinetics of plasma paracetamol levels in postoperative major hepatic surgery (resection greater than or equal to three hepatic segments) comp...
Eligibility Criteria
Inclusion
- Patients requiring surgery for hepatic resection by initiation under chest or laparoscopic without hepatocellular insufficiency,
- ASA score 1 to 3 (American Society of Anesthesiologists score ranging from 1 to 5 evaluating the preoperative health status of a patient),
- Verification of the understanding of the protocol,
Exclusion
- Patients classified ASA 4 or 5,
- Allergy or intolerance to indocyanine green
- Allergy or intolerance to paracetamol,
- Taking of paracetamol the week before the intervention,
- Patient less than 60 Kgs (because decrease of doses of paracetamol),
- Emergency surgery, palliative surgery and surgical recovery,
- Psychic disorder,
- Contra-indication to a treatment used during the study,
- incapable major,
- Intellectual incapacity preventing proper understanding of the protocol,
- Pregnant or nursing woman,
Key Trial Info
Start Date :
November 20 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2019
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT03297073
Start Date
November 20 2016
End Date
November 1 2019
Last Update
December 23 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hôpital Huriez, CHRU
Lille, France