Status:
UNKNOWN
Clinical Outcomes With Electroconvulsive Therapy: Insights From Computational Modelling
Lead Sponsor:
The University of New South Wales
Collaborating Sponsors:
Wesley Mission
Conditions:
Depression
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This study will generate new information on how to optimise brain targets with ECT stimulation.
Detailed Description
This study will differentiate the brain regions which are related to the effectiveness of electroconvulsive therapy (ECT) as a treatment, from the brain regions associated with memory impairment, with...
Eligibility Criteria
Inclusion
- Aged ≥18 years; right-handed
- DSM-5 Major Depressive Episode
- Prescribed with a course of ECT
Exclusion
- Diagnosis (as defined by DSM-V) of psychotic disorder (apart from Major Depressive Episode with Psychotic features), current drug or alcohol abuse or dependence;
- ECT treatments in last 3 months from a prior course of ECT;
- Score \<23 on the Montreal Cognitive Assessment Battery (MoCA);
- Past or current neurological illness or injury, medical illness which may significantly affect neuropsychological function;
- Inability to give informed consent or comply with study procedures; or
- Not having worked or studied in an English speaking background (to ensure validity of neuropsychological testing).
- Not be claustrophobic (if having an MRI brain scan).
- Not have any metal in your head or body (if having an MRI brain scan).
- Likely non response to RUL forms of ECT, as indicated by past non response to RUL ECT
Key Trial Info
Start Date :
October 10 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 22 2022
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT03297411
Start Date
October 10 2017
End Date
June 22 2022
Last Update
May 16 2018
Active Locations (1)
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1
Wesley Hospital Kogarah
Sydney, New South Wales, Australia, 2217