Status:
ACTIVE_NOT_RECRUITING
iFR Guided Multi-vessel Revascularization During Percutaneous Coronary Intervention for Acute Myocardial Infarction
Lead Sponsor:
Radboud University Medical Center
Collaborating Sponsors:
Volcano Europe BVBA/SPRL
Biotronik AG
Conditions:
Acute Myocardial Infarction
Multi Vessel Coronary Artery Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In patients with acute ST-elevation myocardial infarction (STEMI), 40-60% have multi-vessel disease with an increased cardiovascular morbidity and mortality. Although it is not recommended to revascul...
Detailed Description
Study design: The study is a prospective, randomized controlled, multicentre study. Study population: The research population will be recruited from the general patient population presenting with a...
Eligibility Criteria
Inclusion
- Clinical presentation of STEMI and successful primary PCI within 12 hours from onset of symptoms.
- One or more other, noninfarct coronary artery lesions of \>50% stenosis and feasible to be revascularized (i.e. minimal diameter 2mm).
Exclusion
- History of myocardial infarction.
- Hemodynamic instability, respiratory failure, Kilips class ≥III.
- Known GFR\<30 ml/min.
- Known contra-indications for stress CMR (e.g.: severe claustrophobia, metal implants, severe renal failure, severe astma).
- Refusal or inability to provide informed consent.
- Life expectancy due to noncardiovascular co-morbidity of less than 12 months.
- Chronic total occlusion.
- Left main stem stenosis (\>50%).
- Residual noninfarct lesion in infarct coronary artery.
- Complex (e.g. bifurcation) noninfarct target lesions.
Key Trial Info
Start Date :
December 21 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2027
Estimated Enrollment :
1146 Patients enrolled
Trial Details
Trial ID
NCT03298659
Start Date
December 21 2017
End Date
May 31 2027
Last Update
April 4 2025
Active Locations (1)
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1
Radboudumc
Nijmegen, Netherlands