Status:
COMPLETED
PREventing CHemotherapy Induced Neuropathy (PreChIN)
Lead Sponsor:
National University Hospital, Singapore
Conditions:
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Eligibility:
All Genders
21-80 years
Phase:
NA
Brief Summary
The project is designed to study the use of localized hypothermia alone, or with compression to the limbs during chemotherapy infusion for the prevention of chemotherapy induced peripheral neuropathy ...
Detailed Description
Localized limb hypothermia during chemotherapeutic infusion may prevent a common side effect of chemotherapy: chemotherapy-induced peripheral neuropathy (CIPN). There are no reliable methods for the p...
Eligibility Criteria
Inclusion
- The inclusion criterion for the healthy subjects
- Age 21-80 years
- Signed informed consent from patient
- No history of neuropathy
- ECOG 0
- No history of hospitalization in the past 6 months
- The inclusion criteria for the cancer patients undergoing taxane-based chemotherapy
- Age 21- 80 years.
- Signed informed consent from patient or legal representative.
- Scheduled to receive taxane-based chemotherapy
- The exclusion criteria for both healthy subjects and cancer patients
- Open skin wound or ulcers of the limbs
- A score of more than 5 in the Total Neuropathy Score (TNS) at baseline (Not applicable for healthy subjects)
- History of Raynaud's phenomenon, peripheral vascular disease, or poorly controlled diabetes
Exclusion
Key Trial Info
Start Date :
June 13 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 15 2017
Estimated Enrollment :
89 Patients enrolled
Trial Details
Trial ID
NCT03299582
Start Date
June 13 2013
End Date
February 15 2017
Last Update
October 3 2017
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