Status:
COMPLETED
Synaptic Injury and Functional Connectivity in Alzheimer's Disease
Lead Sponsor:
Ohio State University
Conditions:
Alzheimer Disease, Late Onset
Eligibility:
All Genders
60-95 years
Brief Summary
The purpose of this study is to examine cross-sectional associations between CSF markers of synaptic injury (Ng and SNAP-25) and functional connectivity in default and semantic memory networks using 3...
Detailed Description
SPECIFIC AIMS: Aim 1: Investigate correlations between CSF biomarkers of synaptic injury (Ng and SNAP-25) and functional connectivity (FC) within the default mode network (DMN) using resting-state fM...
Eligibility Criteria
Inclusion
- Inclusion Criteria: Participants included in the study should meet all 4 inclusion criteria:
- 60 years of age or older
- A clinical diagnosis of MCI, mild AD dementia, or normal cognition
- No significant medical or surgical co-morbidities
- No contraindications to LP or MRI.
- Exclusion criteria: Participants with any of the following criteria will be excluded from the study:
- Participants with MCI due to AD or mild AD dementia who have been treated with cholinesterase inhibitors or glutamate antagonists in the 3 months prior to study enrollment
- Individuals with any past history of ischemic or traumatic brain injury
- Individuals with imaging evidence of significant cerebrovascular disease or structural brain lesions (e.g. tumor, demyelinating disorders, infection, or congenital anomalies)
- Active mood disorder
- Active alcohol use
- Active use of benzodiazepines, barbiturates, anticholinergic, or anti-epileptic medications
Exclusion
Key Trial Info
Start Date :
February 12 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 22 2021
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT03300726
Start Date
February 12 2018
End Date
September 22 2021
Last Update
September 28 2021
Active Locations (1)
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1
The Ohio State University Wexner Medical Center
Columbus, Ohio, United States, 43210