Status:
COMPLETED
Effect Sildenafil and Estradiiol Valerate on Endometrial Thickness in Infertile Women
Lead Sponsor:
Ain Shams University
Conditions:
Endometrial Thickness
Eligibility:
FEMALE
20-35 years
Phase:
NA
Brief Summary
The endometrium is a dynamic tissue that responds to changing hormonal signals throughout the cycle. The changes in the endometrial composition are expressed in alteration in gene expression, micro ar...
Detailed Description
Being a hormone dependent tissue, the endometrium proliferates in response to estrogen, which further induces the production of progesterone receptors. As a result, infertile patients who demonstrated...
Eligibility Criteria
Inclusion
- Patients having ovulatory infertility.
- Age: 20-35 years old.
- BMI less than 30 kg/m2
Exclusion
- Women who have any congenital uterine anomaly (e.g., unicornuate uterus or infantile uterus) or acquired deformities of the uterine cavity that interfere with embryo implantation (as Asherman Syndrome).
- Women who have any tubal factor that relates to infertility (e.g., tubal adhesion or previous ectopic pregnancy).
- Women who have contraindication for estrogen treatment (e.g., history of stroke, DVT and Benign liver disease).
- Women who have male factor for infertility (e.g., azoospermia, teratospermia).
Key Trial Info
Start Date :
November 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 30 2018
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT03301233
Start Date
November 1 2017
End Date
July 30 2018
Last Update
August 14 2018
Active Locations (1)
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1
Ain Shams University
Cairo, Egypt