Status:
WITHDRAWN
Role of Chemokine and Chemokine Receptor in Psoriasis
Lead Sponsor:
University of California, Davis
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conditions:
Psoriasis
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to elucidate the role of Chemokine and chemokine receptor in the pathogenesis of Psoriasis by using human psoriasis skin xenograft SCID mouse model. The hypothesis is that chemokine an...
Detailed Description
Chemokines belongs to a large group of small chemotactic proteins (8-11 kilodaltons in size). Upon engagement of chemokine, chemokine receptor can activate downstream intracellular signaling pathways ...
Eligibility Criteria
Inclusion
- Subjects 18 years of age or greater
- Subjects need to fulfill the diagnostic evidence of psoriasis with or without psoriatic arthritis
- Subject may take the following medicines: NSAID, hydroxychloroquine, sulfasalazine, prednisone (\<10 mg/day), Methotrexate (10 mg/week)
- Subject needs to stop topical skin preparations other than emollients in one small plaque of psoriasis for 3-4 wks from where the shave biopsy will be taken
- Willing and able to provide informed consent in English
Exclusion
- Subjects less than 18 years old
- no clinical evidence of psoriatic skin
- Subjects with contraindications for biopsy, and patients receiving anticoagulants
- Subjects with active hepatitis B or Hepatitis C infection
- Subjects with concomitant inflammatory diseases such as inflammatory bowel disease, gout
- Subjects who are taking the following systemic biological therapies for psoriasis: cyclosporine, methotrexate, prednisone, acitretin, sulfasalazine, certolizumab, etanercept, adalimumab, infliximab, golimumab, secukinumab, ustekinumab, and apremilast. Other systemic medications may exclude the subject from the study.
Key Trial Info
Start Date :
April 17 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 13 2018
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03302390
Start Date
April 17 2017
End Date
April 13 2018
Last Update
October 17 2018
Active Locations (1)
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1
UC Davis
Sacramento, California, United States, 95817