Status:
COMPLETED
Cerebral MRI During Sleep
Lead Sponsor:
University of California, San Diego
Conditions:
Sleep
Eligibility:
All Genders
18-59 years
Brief Summary
Recent studies in animal models have suggested a critical role for cerebrospinal fluid and Interstitial fluid flux through cerebral parenchyma for removal of byproducts of cellular metabolism and henc...
Detailed Description
Recent studies in animal models have suggested a critical role for cerebrospinal fluid (CSF) / Interstitial fluid (ISF) flux through cerebral parenchyma for removal of byproducts of cellular metabolis...
Eligibility Criteria
Inclusion
- Healthy Adults
Exclusion
- age not in range 18-59
- smoking / recreational drug use
- pregnant women / breast feeding
- contraindication to MRI
- contraindications to Zaleplon
- history of cardiovascular pulmonary or cerebral disease (hypertension (diastolic \>90 mmHg, systolic \> 150 mmHg), unstable cerebrovascular syndromes, prior history of cardiac arrhythmias, unstable angina, chronic obstructive pulmonary disease).
- Current SSRI antidepressant medication
- History of sleep disorder or currently taking sedative / stimulant medication
Key Trial Info
Start Date :
October 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 31 2018
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT03304652
Start Date
October 1 2017
End Date
October 31 2018
Last Update
March 14 2019
Active Locations (1)
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1
UC San Diego
San Diego, California, United States, 92093-0677