Status:
COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.
Lead Sponsor:
Odense University Hospital
Collaborating Sponsors:
University of Southern Denmark
Conditions:
Type 2 Diabetes Mellitus
Eligibility:
All Genders
40-70 years
Phase:
NA
Brief Summary
Several free fatty acids receptors (FFARs) have been discovered. These have been implicated in metabolic processes and inflammation. Consequently, these receptors have attracted interest as targets fo...
Detailed Description
Type 2 diabetes (T2D) is one of the greatest health challenges worldwide. The disease is strongly associated with obesity, and develops via pre-diabetic conditions, where insulin resistance and low-gr...
Eligibility Criteria
Inclusion
- Inclusion criteria: body mass index of 27.5-40 kg/m2 and age between 40-70 years. Healthy subjects, non-smoking, without a close relative history of diabetes, no usage of prescription drugs or dietary supplements within the past month (birth control allowed). Subjects should be able to give informed consent and have no trouble swallowing capsules.
- Exclusion criteria: impaired glucose tolerance measured as two hours OGTT glucose concentration above 7.7 mmol/l, abnormal screening blood samples, food allergies, more than 3kg weight change or restrictive dieting two months prior, severe hypertension or history of gastrointestinal disease or surgery.
Exclusion
Key Trial Info
Start Date :
February 6 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 23 2017
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT03305367
Start Date
February 6 2017
End Date
August 23 2017
Last Update
December 13 2018
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Endocrinology
Odense, Denmark, 5000