Status:
TERMINATED
Recovery After Dialysis-Requiring Acute Kidney Injury
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
The Recovery After Dialysis-Requiring Acute Kidney Injury (RAD-AKI) Pilot Study is a 2-arm randomized clinical trial of hospitalized patients with dialysis-requiring acute kidney injury (RAD-AKI), com...
Detailed Description
The recent landmark Artificial Kidney Initiation in Kidney Injury (AKIKI) trial showed that a delayed strategy for RRT initiation among patients with incident stage 3 AKI - in which RRT was delayed un...
Eligibility Criteria
Inclusion
- Adult inpatients with AKI-D due to acute tubular necrosis who have already initiated renal replacement therapy
- If initiated on CRRT, patients will be eligible only if they have already tolerated 1 intermittent hemodialysis (IHD) session at the research site.
- If transferred from an outside hospital, eligible patients must have tolerated 1 IHD session at the research site prior to enrollment.
- Not requiring vasopressor support
- Not intubated and not having a supplemental oxygen requirement of \>5 L/min via nasal cannula
- Treating MDs (nephrology and primary team attendings) and patient (or legally authorized representative) consent to enrollment
Exclusion
- Diagnosis of end-stage renal disease (ESRD) or chronic dialysis prior to hospitalization
- Baseline estimated glomerular filtration rate (eGFR) \<15 mL/min/1.73m2
- Liver transplant unit patients
- Patients who underwent kidney transplantation during index hospitalization
- Cause of AKI-D is complete nephrectomy
- Current pregnancy
Key Trial Info
Start Date :
September 29 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 13 2019
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT03305549
Start Date
September 29 2017
End Date
November 13 2019
Last Update
March 19 2025
Active Locations (1)
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1
UCSF Medical Center Moffitt-Long Hospital
San Francisco, California, United States, 94143