Status:
COMPLETED
The Role of Circuit Flow During Mechanical Ventilation of Neonates
Lead Sponsor:
Cambridge University Hospitals NHS Foundation Trust
Conditions:
Respiratory Distress Syndrome in Premature Infant
Eligibility:
All Genders
1-2 years
Phase:
NA
Brief Summary
During neonatal mechanical ventilation inflating pressures, tidal volumes, and inflation and expiration times need to be set and adjusted to optimise oxygenation and carbon dioxide removal. The flow o...
Detailed Description
\- Background of the project About 1.5% of newborns require mechanical ventilation. Although mechanical ventilation can be life-saving for neonates with respiratory failure, it may cause lung injury ...
Eligibility Criteria
Inclusion
- Birth weight \< 2 kg;
- Ventilated with SIPPV-VG modes,
- Informed parental consent,
- Clinician assent.
Exclusion
- Baby's respiratory condition unstable (Inspired oxygen (FiO2) \> 50%, PaCO2 \> 8.5kPa or \<5kPa in the last 12 hours)
- Extubation planned in the next 12 hours;
- Neonatal or surgical procedure in the last 12 hours or planned in the next 12 hours;
- Significant pneumothorax requiring drainage;
- Gas leak around the endotracheal tube \>50%; #
- No arterial access;
- The responsible clinician does not agree with recruitment;
- Parents do not consent.
Key Trial Info
Start Date :
July 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2018
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT03306524
Start Date
July 1 2017
End Date
June 30 2018
Last Update
May 20 2019
Active Locations (1)
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1
Neonatal Intensive Care Unit, Cambridge University Hospitals NHS Trust
Cambridge, United Kingdom, CB20QQ