Status:
RECRUITING
Mirror Neuron Network Dysfunction as an Early Biomarker of Neurodevelopmental Disorder
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Developmental Delay
Eligibility:
All Genders
9-65 years
Brief Summary
Background: People show changes in brain activity when they watch other people do actions. This may be part of early social and communication skills. Researchers want to understand the stages of norm...
Detailed Description
Objective: This investigation has two main objectives: 1) combine two child-friendly brain imaging techniques and stochastic modeling to determine the neural basis for the development of imitation and...
Eligibility Criteria
Inclusion
- INCLUSION CRITIERIA:
- Healthy adults
- Age of 18-65 at study entry
- Healthy and good condition as determined by medical history and physical examination
- Healthy Infants
- 9 months +/- 2 weeks of age at time of consent
- Healthy and good condition as determined by medical history and physical examination
- Age appropriate development as determined by parent report and exam
- Full term at birth
- Normal weight for gestational age
- At Risk Infants
- 12 months +/- 2 weeks at the time of consent
- Must have at least one of the following: observed developmental delay; sibling of a child with autism; premature birth; small for gestational age
- EXCLUSION CRITERIA:
- Healthy Adults
- Uncorrected auditory impairment
- Uncorrected visual impairment
- Head injury with loss of consciousness
- Inability to provide consent
- Subject has a condition, that in the opinion of the investigator, creates an unacceptable risk for participation
- Healthy and At-Risk Infants
- A language other than English as the primary language spoken at home
- Having a medical impairment that interferes with study participation such as having a g-tube, shunt or seizure disorder and inability to hold one s head upright
- Having a known visual impairment
- Having a known auditory impairment
Exclusion
Key Trial Info
Start Date :
August 30 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2031
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03307317
Start Date
August 30 2018
End Date
February 1 2031
Last Update
September 22 2025
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892