Status:
COMPLETED
The Analysis of Factors Influencing the Vd of Imipenem in Septic Shock Patients
Lead Sponsor:
Southeast University, China
Conditions:
Septic Shock
Eligibility:
All Genders
18-80 years
Brief Summary
The study measures the plasma concentrations of imipenem in septic shock patients and non-septic shock patients and observes hypoalbuminemia and the impact of the severity of critical illness on Vd
Detailed Description
Severe sepsis and septic shock are major causes of mortality in intensive care unit(ICU) patients.Correct and adequate antibiotic coverage is essential but can be complex as a result of fluid resuscit...
Eligibility Criteria
Inclusion
- age between 18 years old and 80 years old;
- Admitted to the ICU;
- Patients diagnosed as septic shock requiring the therapy of imipenem(0.5g q6h or 1.0g q8h;
Exclusion
- Patient participated in another interventional trial before enrollment
- Allergy, hypersensitivity or a serious reaction to imipenem;
- Pregnancy.
- patients with ECMO and(or)CRRT.
- tumors.
Key Trial Info
Start Date :
March 18 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 28 2018
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT03308214
Start Date
March 18 2018
End Date
December 28 2018
Last Update
January 5 2021
Active Locations (1)
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1
Zhongda Hospital, Southeast University
Nanjing, Jiangsu, China, 210009