Status:
UNKNOWN
Plasma and Lung Tissue Concentrations of Linezolid in Septic Shock Patients
Lead Sponsor:
Southeast University, China
Collaborating Sponsors:
Cttq
Conditions:
Septic Shock
Eligibility:
All Genders
19-75 years
Brief Summary
The study measures the plasma and bronchoalveolar lavage fluid concentrations of linezolid in septic shock patients comparing with non-septic shock patients to confirm the impact of septic shock on PK...
Detailed Description
A wide array of pathophysiological changes occurring in severe sepsis and septic shock patients may influence antibiotics' pharmacokinetic (PK) properties. The pharmacokinetics and tissue distribution...
Eligibility Criteria
Inclusion
- between 18 years old and 75 years old;
- Admitted to the ICU;
- Expectation, in the opinion of the investigator, that the patients' infection will require ICU stay more than 3 days;
- Patients diagnosed as severe pneumonia requiring mechanical ventilatory support;
- Severe pneumonia known or suspected to be caused by Gram-positive pathogens;
- Expected to treat with linezolid.
Exclusion
- Unable to take bronchoalveolar lavage via bronchofiberscopy;
- Allergy, hypersensitivity or a serious reaction to linezolid;
- Treatment with linezolid during the previous 72 hours;
- Pregnancy.
Key Trial Info
Start Date :
October 20 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 30 2018
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT03308227
Start Date
October 20 2017
End Date
April 30 2018
Last Update
October 12 2017
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