Status:
ACTIVE_NOT_RECRUITING
Cracking Coma: Towards EEG and MRI Based Precision Medicine After Cardiac Arrest
Lead Sponsor:
Rijnstate Hospital
Collaborating Sponsors:
University Medical Center Nijmegen
Donders Centre for Cognitive Neuroimaging
Conditions:
Post-Anoxic Coma
Eligibility:
All Genders
18+ years
Brief Summary
Rationale: 30-70% of comatose patients admitted to the intensive care unit (ICU) after cardiac arrest never regain consciousness as a result of post anoxic encephalopathy (PAE). Early identification o...
Detailed Description
Standard procedures: Patients will be monitored and treated according to guidelines for post out of hospital cardiac arrest treatment as described in local ICU protocols. Patients do not suffer any h...
Eligibility Criteria
Inclusion
- Comatose, defined as Glasgow Coma Score ≤ 8
- Age ≥ 18 years
- Cardiac arrest with a presumed cardiac cause of the arrest or caused by pulmonary embolism
- Admission to ICU
Exclusion
- Pregnancy
- Life expectancy \< 24 hours
- Absence of written informed consent (by a legal representative)
- Pre-existing dependency in daily living, defined as CPC score 3 or 4
- Any known progressive brain illness, such as a brain tumor or neurodegenerative disease.
- Known contra-indication for MRI
Key Trial Info
Start Date :
June 11 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03308305
Start Date
June 11 2018
End Date
December 1 2025
Last Update
April 9 2025
Active Locations (3)
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1
Rijnstate Hospital
Arnhem, Gelderland, Netherlands, 6815 AD
2
Radboud University Medical Centre
Nijmegen, Gelderland, Netherlands
3
Maastricht University Medical Center
Maastricht, Netherlands