Status:
COMPLETED
Clinical Efficacy of the Neoadjuvant Chemotherapy for IB2 and IIA2 Stage Cervical Cancer Patients
Lead Sponsor:
Huazhong University of Science and Technology
Conditions:
Uterine Cervical Neoplasm
Cervical Cancer
Eligibility:
FEMALE
Up to 65 years
Phase:
PHASE3
Brief Summary
In recent years, the patients with IB2 and IIA2 stage cervical cancer are still treated with radiotherapy and chemotherapy based treatment, but the radiotherapy will severely damage the function of ov...
Eligibility Criteria
Inclusion
- clinical diagnosis IB2 or IIA2 stage cervical cancer;
- age less than or equal to 65 years old;
- laboratory examination results: WBC ≥ 4\*10\^9/L, NEU ≥ 20\*10\^9/L, PLT ≥ 80\*10\^9/L, serum bilirubin ≤ 2 multiples of the upper normal limit, aminopherase ≤ 2 multiples of the upper normal limit. BUN ≤ normal limit, CR ≤ normal limit;
- KARNOFSKY score ≥ 60;
- No prior treatment;
- pathological diagnosis before surgery is invasive squamous cell carcinoma of cervix;
- well-compliance and willing to keep in touch;
- willing to participate in this study, and sign the informed consent;
Exclusion
- participate in other drug clinical trials at the same time;
- respiratory depression, airway obstruction and hypoxia;
- heart diseases (cardiac function at grade II, III or above);
- hematological diseases;
- obvious dysfunction of liver and kidney (above 3 multiples of the upper normal limit);
- a history of brain dysfunction;
- unable to receive surgery and/or unsuitable for radiotherapy or chemotherapy;
- drug abuse or a history of drug abuse;
- unable or unwilling to sign informed consents;
- unable or unwilling to follow the protocols;
Key Trial Info
Start Date :
January 11 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2022
Estimated Enrollment :
774 Patients enrolled
Trial Details
Trial ID
NCT03308591
Start Date
January 11 2016
End Date
February 1 2022
Last Update
October 31 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430030