Status:
COMPLETED
Inflammaging and Muscle Protein Metabolism
Lead Sponsor:
University of Thessaly
Conditions:
Inflammaging
Sarcopenia
Eligibility:
MALE
63-75 years
Phase:
NA
Brief Summary
The development of a low-grade, chronic, systemic inflammation observed in the elderly (inflammaing) has been associated with increased risk for skeletal muscle wasting, strength loss and functional i...
Detailed Description
A total number of \> 60 male, older adults aged 63-73 years will be initially screened for systemic levels of hs-CRP and IL-6. Of these, 24 individuals that will comply with the study criteria will be...
Eligibility Criteria
Inclusion
- Non-smokers.
- BMI ≥18.5 \& BMI ≤ 35 kg/m2.
- Moderately active but with no regular participation in heavy resistance exercise within the last 6 months.
- Absence of chronic disease (i.e. cancer, metabolic, cardiac, or neurological diseases).
- Free and independently living.
Exclusion
- Organ failure (unstable, renal, respiratory, liver).
- Chronic use of corticosteroid medication.
- Recent use of antibiotics.
- Presence of frailty.
- Body weight variation over the past 6mo \> 10% or weight loss of more than 3kg in the last 3 months.
- Use of anti-inflammatory or lipid-lowering medication (i.e., statins).
- Use of medication interacting with muscle metabolism.
Key Trial Info
Start Date :
September 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 30 2018
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT03308747
Start Date
September 1 2017
End Date
May 30 2018
Last Update
July 19 2018
Active Locations (1)
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1
Exercise Biochemistry Laboratory, School of Physical Education & Sports Sciences, University of Thessaly
Trikala, Greece, 42100