Status:
COMPLETED
The Effect of Blood Pressure on Cerebral Blood Flow During Propofol Anesthesia
Lead Sponsor:
Rigshospitalet, Denmark
Conditions:
Gastrointestinal Neoplasms
Anesthesia, General
Eligibility:
All Genders
19+ years
Phase:
NA
Brief Summary
General anesthesia often reduces blood pressure whereby blood flow to the brain and other vital organs may become insufficient. Thus, medicine is often administered to maintain blood pressure but it i...
Detailed Description
Background Propofol anesthesia reduces cerebral blood flow (CBF) and mean arterial pressure (MAP) but it is unclear whether the decrease in CBF is accentuated by hypotension. Cerebral autoregulation i...
Eligibility Criteria
Inclusion
- Patient planned for Whipple's surgery or total pancreatic resection
- Age \> 18 years
Exclusion
- No informed consent
- Alcohol intake ≥ 420 g / week
- Beard on the neck
- Visualization of the internal carotid artery not possible, e.g. due to high placement of the bifurcation
- Stenosis that obstructs ≥ 16% of the internal carotid artery
- Cardiac disease, including congestive heart failure (NYHA II-IV), myocardial infarction, valvular heart disease or atrial fibrillation
- Neurologic disease considered to affect cerebral blood flow, including dementia, epilepsy, and apoplexy
- Intake of moclobemide, isocarboxazid or tricyclic antidepressants
Key Trial Info
Start Date :
December 27 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 19 2018
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03309917
Start Date
December 27 2017
End Date
April 19 2018
Last Update
July 26 2018
Active Locations (1)
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1
Department of Anaesthesia
Copenhagen, Denmark, DK-2100