Status:
TERMINATED
NAD Supplementation Study
Lead Sponsor:
Maastricht University
Conditions:
Aging
Mitochondrial Function
Eligibility:
All Genders
65-75 years
Phase:
NA
Brief Summary
This research project aims to determine whether supplementing with a mixture of the NAD+-precursors NA, NAM, and tryptophan can stimulate skeletal muscle mitochondrial function in physically compromis...
Eligibility Criteria
Inclusion
- Males and females
- Age ≥ 65 ≤ 75 years;
- BMI ≥ 20 kg/m2 ≤ 30 kg/m2;
- Normal physical activity levels: maximum of 1 hour per week engagement in a structured exercise session;
- SPPB score 4-9 and (pre-)frail;
- Subject should be in sufficient health to participate in the experiments, to be judged by the responsible physician based on the subject's medical history.
Exclusion
- Not meeting all inclusion criteria;
- Smoking;
- Excessive alcohol use and/or drug abuse;
- Subjects with diabetes mellitus type 2;
- Significant food allergies or intolerances concerning the study products;
- Participation in another biomedical study within 1 month before the first study visit, possibly interfering with the study results;
- Medication use known to hamper subject's safety during the study procedures;
- Subjects who use selective serotonin re-uptake inhibitors (SSRI), or selective norepinephrin re-uptake inhibitors (SNRI), or monoamino oxidase inhibitors (MAO-inhibitors), or clomipramine, or St. John's wort (Hypericum perforatum);
- Subjects with contra-indications for MRI;
- Subjects who do not want to be informed about unexpected medical findings;
- Subjects who do not want that their treating physician to be informed;
- Co-morbidities to which the intervention or program the may pose as a complicating factor;
- Inability to participate and/or complete the required measurements.
Key Trial Info
Start Date :
November 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 6 2020
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT03310034
Start Date
November 1 2017
End Date
March 6 2020
Last Update
August 20 2020
Active Locations (1)
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1
Maastricht University
Maastricht, Limburg, Netherlands, 6229ER