Status:
UNKNOWN
Aortic Stenosis in Subjects With Heterozygous Familial Hypercholesterolemia on Prolonged Treatment With Statins
Lead Sponsor:
Instituto Aragones de Ciencias de la Salud
Conditions:
Aortic Stenosis
Arteriosclerosis
Eligibility:
All Genders
55+ years
Brief Summary
Aortic stenosis (AE) is a disease that has been increasing steadily in recent years in most countries, including Spain.Risk factors for the development of AE include age, hypercholesterolemia, diabete...
Detailed Description
The study includes a single clinical visit with collection of clinical data, blood extraction and the performance of a transthoracic echocardiogram. This visit may be made on different days, but alway...
Eligibility Criteria
Inclusion
- Cases:
- Age ≥ 65 years at the time of cardiac ultrasound
- Genetically diagnosed HFH or in a first-degree relative
- History of hypercholesterolemia with LDLc levels\> 220 mg / dL without lipid-lowering treatment
- Controls:
- Genetically Similar
- Siblings of the normoccholesterolemic case, defined by LDLc \<190 mg / dl without lipid-lowering treatment.
- In the absence of available siblings, first cousins may be included.
- In the presence of several siblings available, the same sex will be included,
- Environmentally similar
- Stable partner of the case with cohabitation\> 25 years \* Each case will have at least one control.
Exclusion
- \- Personal history of cardiac rheumatic disease
Key Trial Info
Start Date :
July 18 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 18 2018
Estimated Enrollment :
900 Patients enrolled
Trial Details
Trial ID
NCT03310671
Start Date
July 18 2017
End Date
July 18 2018
Last Update
October 16 2017
Active Locations (1)
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1
Fernando Civeira Murillo
Zaragoza, Spain, 50009