Status:
UNKNOWN
Cerebral Reorganization in Cervical Myelopathy Measured by Navigated Transcranial Magnetic Stimulation
Lead Sponsor:
Charite University, Berlin, Germany
Collaborating Sponsors:
German Spine Society (Deutsche Wirbelsäulenstiftung)
Insel Gruppe AG, University Hospital Bern
Conditions:
Degenerative Myelopathy
Eligibility:
All Genders
18+ years
Brief Summary
In degenerative cervical myelopathy (DCM) the dynamics of disease progression and the outcome after surgical decompression vary inter individually and do not necessarily correlate with radiological fi...
Detailed Description
120 patients with DCM due to cervical spinal canal stenosis will be examined preoperatively and postoperatively with nTMS. On the basis of the initial Japanese Orthopedic Association (JOA) Score two p...
Eligibility Criteria
Inclusion
- patients with symptomatic/asymptomatic cervical spondylotic myelopathy scheduled for surgery (anterior and/ or posterior decompression) or conservative treatment. The radiological inclusion criteria are cervical spinal stenosis (C3-C7) associated with or without intramedullary high signal intensity lesion on T2-weighted MRI due to disc protrusion or spondylosis.
- healthy subjects without any neurological disease
Exclusion
- Exclusion criteria are other pathologies in the vicinity of the corticospinal tract above the lesion site (i.e. tumor, infarction), neuroinflammatory disease, high grade paresis of the upper extremity (BMRC\<3), the existence of a cardiac pacemaker, deep brain stimulation electrodes or pregnancy.
Key Trial Info
Start Date :
January 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2023
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT03312608
Start Date
January 1 2017
End Date
February 1 2023
Last Update
October 18 2017
Active Locations (1)
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1
Department of neurosurgery Charité
Berlin, Germany, 10117