Status:
COMPLETED
Plasma CO2 Removal Due to CRRT and Its Influence on Indirect Calorimetry
Lead Sponsor:
Universitair Ziekenhuis Brussel
Conditions:
Continuous Renal Replacement Therapy
CO2 Removal
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of the present study is to assess the metabolic impact of Continuous Renal Replacement Therapy and overview the obstacles and important factors compromising the use of Indirect Calorimetry in ...
Detailed Description
Acute kidney injury (AKI) complicates a critical illness from 13% up to 78%, needing renal replacement therapy (RRT) up to10 % of all patients in the intensive care unit (ICU). Both intermittent (IRRT...
Eligibility Criteria
Inclusion
- AKI requiring CRRT
- Patient on CRRT who's filter you want to change
- Expected stable patient during the test ( +- 2h) evaluated at discretion of physician :
- No alteration in medication
- Stable respiratory settings where no change in conditions is expected. If possible, controlled mode ventilation is preferred.
- Expected stable pH and lactate
- no intervention will be made on patient (transport/washing/physiotherapy/…)
- no alterations on settings of CRRT is expected to be made.
- Maximal respiratory settings: max FiO2: 60% / max inspiratory plateau pressure 30 mmHg/max tidal volumes 8ml/kg
- pH between 7,30-7,50, lactate levels \<2,0
- starting settings CRRT with citrate:
- Blood pump flow: 150 ml/min
- Predilution ( citrate): 1500-2300ml/h
- Dialysate dose: 25-40 ml/kg/h
- ultrafiltration: 0-300 ml /h
- Substitution: NaCl 300-800 ml/h or B22: 400-2000 ml/h
Exclusion
- Pregnancy / lactation
- Contra-indications for the use of indirect calorimetry as stated by the AARC (FiO2\>60%, chest tubes)
- Severe hemodynamic or ventilator instability.
- CRRT modalities unusual to daily clinical ICU practice
Key Trial Info
Start Date :
April 26 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 15 2019
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT03314363
Start Date
April 26 2017
End Date
March 15 2019
Last Update
May 18 2022
Active Locations (1)
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1
universitair ziekenhuis Brussel
Brussels, Belgium, 1090