Status:
COMPLETED
Revised Simplified Algorithm for Treatment Eligibility for HIV (SLATEII)
Lead Sponsor:
Boston University
Collaborating Sponsors:
University of Witwatersrand, South Africa
Bill and Melinda Gates Foundation
Conditions:
HIV/AIDS
Antiretroviral Therapy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In its 2017 revision of the global guidelines for HIV care and treatment, the World Health Organization called for rapid or same-day initiation of antiretroviral treatment (ART) for eligible patients ...
Detailed Description
SLATE II is be a pragmatic, individually randomized evaluation to determine the effectiveness of the revised algorithm in increasing ART initiation, compared to standard care, among non-pregnant adult...
Eligibility Criteria
Inclusion
- Adult patients (\>18 years) (initiating children and adolescents on ART is likely to require additional information and adherence support, making the SLATE algorithm less applicable to pediatric populations)
- Confirmed HIV-positive test result at any time (may have been diagnosed previously)
- Self-report that patient is not currently on ART and has not been prescribed ART in the past three months
- Presented at the study clinic for any HIV-related reason or other reason that led to referral for HIV testing or care
Exclusion
- Pregnant (pregnancy is an exclusion criterion because treatment guidelines for pregnant women differ from those for non-pregnant adults; most pregnant women are diagnosed with HIV and initiated on ART in antenatal clinics, not general adult HIV clinics)
- Not intending to return to this clinic for further HIV care in the coming year (i.e. intends to seek further care somewhere else)
- Not willing to be traced by phone or in person for follow-up care if test results received after the enrollment visit indicate that further care is needed
- Not physically, mentally, or emotionally able to participate in the study, in the opinion of the investigators or study staff
- Not willing or able to provide written informed consent to participate in the study
- Previously enrolled in the same study or the SLATE I study
Key Trial Info
Start Date :
March 14 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2020
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT03315013
Start Date
March 14 2018
End Date
December 31 2020
Last Update
January 22 2021
Active Locations (1)
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1
Health Economics and Epidemiology Research Office
Johannesburg, Gauteng, South Africa