Status:
UNKNOWN
Efficacity and Safety of Mechanical Insufflation-exsufflation on ICU
Lead Sponsor:
University Hospital, Bordeaux
Collaborating Sponsors:
Sociedad Española de Neumología y Cirugía Torácica
Conditions:
Mucus Retention
Mechanical Ventilation Complication
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Critically ill and intubated patients on mechanical ventilation (IMV) often present retention of respiratory secretions, increasing the risk of respiratory infections and associated morbidity. Endotra...
Detailed Description
Controlled randomized, cross-over, single blind trial conducted at University Hospital of Bordeaux (France). Inclusion criteria: Patients (\>18 yo) intubated \[internal diameter (ID) 7 to 8\], sedate...
Eligibility Criteria
Inclusion
- Inclusion criteria :
- Patients over 18 years old.
- Patents endotracheally intubated (tubes between 7mm and 8mm of internal diameter).
- Invasive mechanical ventilation \> 48h
- Invasive mechanical ventilation expected \> 24h
- RASS between -3 and -5
- Exclusion criteria :
- Lung disease with pulmonary parenchyma injury or diseases where mechanical insufflation-exsufflation use is not recommended (eg: emphysema, pneumothorax, pneumomediastinum, hemoptyses, airway instability, acute barotrauma).
- Hemofiltered patients through a central jugular catheter.
- Respiratory instability (FiO2) \>60% and/or (PEEP) \> 10cmH2O, and/or hemodynamic instability (MAP) \< 65mmHg although use of vasopressors)\] instability
- Patients on strict dorsal decubitus by medical prescription.
- High risk infection patients (eg: tuberculosis, H1N1) that cannot be disconnected from IMV.
Exclusion
Key Trial Info
Start Date :
March 6 2015
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2017
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT03316079
Start Date
March 6 2015
End Date
December 1 2017
Last Update
October 20 2017
Active Locations (3)
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1
Medical ICU
Bordeaux, France, 33000
2
Vascular ICU.
Bordeaux, France, 33000
3
Polyvalent ICU. Centre medico-chirurgicale Magellan 2.
Pessac, France, 33600