Status:
COMPLETED
The Interaction Between Metformin and Physical Training
Lead Sponsor:
Kristian Karstoft
Collaborating Sponsors:
University of Copenhagen
Conditions:
Impaired Glucose Tolerance
Diabetes Mellitus, Type 2
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Physical activity is a first line treatment for patients with type 2 diabetes (T2D), however, the vast majority of patients with T2D do not achieve satisfying glycemic control with physical activity a...
Eligibility Criteria
Inclusion
- Glucose-lowering-medication naïve T2D and/or subjects with impaired glucose tolerance defined as: 2-h plasma glucose (PG) in the 75-g OGTT (7.8-11.0 mmol/L) and/or HbA1c (39-47 mmol/mol)
- Caucasian
- BMI \> 25 but \< 40 kg/m2
- Low to moderate physically active (≤90 min of structured physical activity/week)
Exclusion
- Pregnancy
- Smoking
- Glucose-lowering treatment
- Treatment with steroids and other immunomodulating drugs
- Contraindication to increased levels of physical activity
- Liver disease (ALAT elevated more than 3 times above upper normal limit, or reduce levels of the liver function markers albumin and KF II+VII+X)
- Renal insufficiency (eGFR\<60 ml/min)
- Prior history of lactic acidosis
- HbA1c \>55 mmol/mol and/or 2-hPG in the 75-g OGTT \> 15 mmol/L
Key Trial Info
Start Date :
October 20 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2018
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT03316690
Start Date
October 20 2017
End Date
October 1 2018
Last Update
November 9 2018
Active Locations (1)
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1
Center for aktiv sundhed
Copenhagen, Copenhagen N, Denmark, 2200