Status:
COMPLETED
the Effect of Dopamine on Mechanical Ventilation Induced Lung Injury
Lead Sponsor:
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Conditions:
Acute Lung Injury
Eligibility:
All Genders
18-60 years
Brief Summary
Dopamine(DA) is a common neurotransmitter that has been known to regulate behavior, movement, cardiovascular，endocrine and gastrointestinal functions, but also functions as an important molecule engag...
Detailed Description
Mechanical ventilation is a critical intervention for patients with acute respiratory failure. However, lung overdistension induced by mechanical ventilation at high tidal volumes also causes pulmonar...
Eligibility Criteria
Inclusion
- Patients inclusion criteria: undergo elective lobectomy with general anesthesia and mechanical ventilation; classified as physical status I to III according to the American Society of Anesthesiologists Physical Status Classification System; Written informed consent is approved.
Exclusion
- Distant metastases: recent anaesthetics or mechanical ventilation treatment；children；women during pregnancy or lactation; being involved in other clinical subjects.
Key Trial Info
Start Date :
March 20 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2017
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT03317431
Start Date
March 20 2017
End Date
December 1 2017
Last Update
October 22 2018
Active Locations (1)
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1
Department of Anesthesia, Shanghai Xinhua hospital
Shanghai, Shanghai Municipality, China, 200082