Status:
COMPLETED
Maternal Lipids and Offspring Adiposity at 5-7 Years
Lead Sponsor:
Belfast Health and Social Care Trust
Collaborating Sponsors:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Adiposity
Eligibility:
FEMALE
18+ years
Brief Summary
This study investigates the associations between measured maternal lipids (Total cholesterol, LDL-cholesterol , triglycerides and high-density lipoprotein cholesterol) at 28 weeks' gestation and offsp...
Detailed Description
The concept of fuel mediated teratogenesis, as proposed by Freinkel in his 1980 Banting Lecture, postulated that altered fuel metabolism during pregnancy had a long lasting metabolic effect on the off...
Eligibility Criteria
Inclusion
- In a pregnant state in the first/second trimester
- Attending the Royal Victoria Maternity Hospital
Exclusion
- Age younger than 18 years
- A plan to undergo delivery at another hospital
- An uncertain date of last menstrual period and no ultrasonographic estimation between 6 and 24 weeks of gestational age
- Inability to complete the oral glucose-tolerance test within 32 weeks of gestation
- Multiple pregnancy
- Conception by means of gonadotropin ovulation induction or in vitro fertilization
- Glucose testing before recruitment or a diagnosis of diabetes during the current pregnancy
- Diagnosis of diabetes before the current pregnancy and requiring treatment with medication
- Participation in another study that could interfere with the HAPO study
- Infection with the human immunodeficiency virus or hepatitis B or C virus
- Previous participation in the HAPO study
- Inability to converse in the languages used on centre forms without the aid of an interpreter
Key Trial Info
Start Date :
January 9 2001
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 14 2012
Estimated Enrollment :
1224 Patients enrolled
Trial Details
Trial ID
NCT03317522
Start Date
January 9 2001
End Date
March 14 2012
Last Update
October 23 2017
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