Status:
RECRUITING
Improving Measurement and Treatment of Post-stroke Neglect
Lead Sponsor:
VA Office of Research and Development
Conditions:
Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study examines how to best assess and treat post-stroke neglect. This study will examine the preliminary effects of an innovative intervention (repetitive task-specific practice + transcranial di...
Detailed Description
It is very common for stroke survivors to have difficulty attending to one side of their body or space (neglect). Stroke survivors with neglect not only demonstrate impairments in attention but they a...
Eligibility Criteria
Inclusion
- Ischemic or hemorrhagic stroke 3 months post stroke.
- Fugl-Meyer Upper Extremity (FMA-Upper Extremity) score between 20-56/60
- Inducible motor evoked potential (MEP) of the abductor pollicis brevis (APB) on the paretic stimulation (TMS)
- Demonstrate the presence of unilateral neglect (Virtual Reality Lateralized Attention Test score \<18)
Exclusion
- History of cortical hemorrhagic stroke
- Presence of any MRI, TMS, tDCS risk factors including:
- history of seizures
- history of brain tumor
- hardware in skull or spine (e.g. coils, clips)
- implantable medical device (e.g. pacemaker)
- metal in body (not compatible with MRI)
- pregnancy
- Severe spasticity (Modified Ashworth Scale score 3)
- Severe aphasia or cognitive impairment limiting participants' comprehension (National Institutes of Health Stroke Scale Level of Consciousness Commands Item score 1 or Best Language Item score 2)
- Unable to travel to UE Motor Function Laboratory at the Center for Rehabilitation Research in Neurological Conditions (a collaborative, MOU approved, research center Ralph H. Johnson VA Medical Center and the Medical University of South Carolina) for the study
Key Trial Info
Start Date :
July 2 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2026
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT03317860
Start Date
July 2 2018
End Date
September 30 2026
Last Update
September 17 2025
Active Locations (1)
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1
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
Pittsburgh, Pennsylvania, United States, 15240