Status:

COMPLETED

Renal Transplant Injury and the Renin-Angiotensin System in Kids (RETASK)

Lead Sponsor:

Wake Forest University Health Sciences

Collaborating Sponsors:

Stanford University

Conditions:

Renal Transplant

Renin-Angiotensin System

Eligibility:

All Genders

1-20 years

Brief Summary

In pediatric kidney transplant patients, rejection, medication toxicity and ischemia cause early and chronic renal allograft injury, which reduces graft lifespan and patient survival. Early detection ...

Detailed Description

Kidney damage activates the traditional renin-angiotensin (Ang) system (RAS), characterized by Ang-converting enzyme (ACE)/Ang II/Ang II type 1 receptor. The Ang-converting enzyme 2 (ACE2)/Ang-(1-7)/M...

Eligibility Criteria

Inclusion

  • Ages 1 - 20 years
  • Actively listed on the transplant list at Lucile Packard Children's Hospital at Stanford and received a renal transplant during the study enrollment period

Exclusion

  • Transplanted at a center other than Lucile Packard Children's Hospital at Stanford

Key Trial Info

Start Date :

July 16 2014

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

April 26 2017

Estimated Enrollment :

29 Patients enrolled

Trial Details

Trial ID

NCT03317925

Start Date

July 16 2014

End Date

April 26 2017

Last Update

November 8 2017

Active Locations (1)

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Page 1 of 1 (1 locations)

1

Wake Forest University Baptist Medical Center

Winston-Salem, North Carolina, United States, 27157