Status:
COMPLETED
Exercise Training in Dystonia
Lead Sponsor:
University of Florida
Conditions:
Dystonia
Eligibility:
All Genders
30-80 years
Phase:
NA
Brief Summary
The purpose of this research study is to investigate how the brain and motor behavior changes in individuals with dystonia and other involuntary movement disorders and healthy individuals over time wi...
Detailed Description
The study team plan to conduct a randomized prospective, parallel-group, controlled study to examine the effects of exercises in dystonia and other involuntary movement disorders. Patients will be ran...
Eligibility Criteria
Inclusion
- Patients with dystonia and other involuntary movement disorders will be recruited whose diagnosis will be confirmed by a Movement Disorders specialist following the criteria recommended by movement disorders society.
- Patients will be eligible if they are ages 30 to 80 years,
- Receive stable doses of regular botulinum toxin injections and are on stable doses of oral pharmacological therapy if applicable, and are able to walk for 6 minutes.
- Age-matched healthy individuals will be recruited for normative data.
- All individuals must be capable of providing informed consent and complying with the study related procedures.
Exclusion
- Patients will be ineligible if they have a neurological history other than dystonia, have significant arthritis
- Fail the Physical Activity Readiness Questionnaire, have cognitive impairment as indicated by a Mini Mental State Examination score \<23,
- Already exercising.
- As necessitated by the risks of Magnetic Resonance Imaging (MRI) or transcranial magnetic stimulation (TMS), patients who have any type of implanted electrical device (such as a cardiac pacemaker or a neurostimulator), or a certain type of metallic clip in their body (i.e., an aneurysm clip in the brain)
- Active seizure disorder are not eligible for participation in the MRI or TMS portion of the study.
- Individuals who are claustrophobic will also be excluded from participation.
- Women who are or might be pregnant and nursing mothers are not eligible. Pregnancy tests will be carried out for each female subject of child bearing potential prior to the participation in the study and prior to each follow up visit.
Key Trial Info
Start Date :
November 6 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 24 2022
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT03318120
Start Date
November 6 2017
End Date
June 24 2022
Last Update
September 21 2022
Active Locations (1)
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1
University of Florida
Gainesville, Florida, United States, 32611