Status:
COMPLETED
Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
Foundation for Anesthesia Education and Research
GlaxoSmithKline
Conditions:
Subarachnoid Hemorrhage, Aneurysmal
Delayed Cerebral Ischemia
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
Soluble epoxide hydrolase (sEH) is the metabolizing enzyme of epoxyeicosatrienoic acids (EETs), which may play a role in reducing neuroinflammation and regulating cerebral blood flow after subarachnoi...
Detailed Description
Study Description: Soluble epoxide hydrolase (sEH) is the metabolizing enzyme of epoxyeicosatrienoic acids (EETs), which may play a role in reducing neuroinflammation and regulating cerebral blood flo...
Eligibility Criteria
Inclusion
- Age \> 18
- Head CT evidence of subarachnoid hemorrhage
- Digital subtraction cerebral angiography or CT angiogram documenting the presence of a cerebral aneurysm.
Exclusion
- Symptom onset compatible with SAH of \> 3 days prior to admission to OHSU
- Absence of an indwelling external ventricular drain
- Administration of any of the following inducers/inhibitors of CYP3A4: ritonavir, indinavir, nelfinavir, saquinavir, clarithromycin, telithromycin, chloramphenicol, ketoconazole, itraconazole, nefazodone, cobicistat or enzalutamide.
- Suspected or confirmed pregnancy
- Preexisting severe neurologic deficit or condition
- Chronic renal failure requiring dialysis
- Severe terminal disease with life expectancy \<6 months
- Unable to read or understand written or spoken English or Spanish
- Refusal of informed consent
Key Trial Info
Start Date :
May 2 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 9 2020
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03318783
Start Date
May 2 2018
End Date
January 9 2020
Last Update
January 22 2021
Active Locations (1)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97239