Status:
COMPLETED
DHFR 19 bp Deletion Polymorphism and Folic Acid Utilization
Lead Sponsor:
Tufts University
Conditions:
Characterize rs70991108 Polymorphism of DHFR Gene
Eligibility:
FEMALE
21-45 years
Brief Summary
A genetic variation in the gene for the protein dihydrofolate reductase (DHFR) that is necessary to utilize folic acid (a synthetic form of the B vitamin folate found in supplements and fortified food...
Detailed Description
A 19bp deletion polymorphism of intron 1 of dihydrofolate reductase (DHFR 19bpdel) increases the risk for breast cancer, and retinoblastoma of the offspring, in folic acid supplement users. Folic acid...
Eligibility Criteria
Inclusion
- Adult premenopausal women aged 21-45 in general good health, non-pregnant, minimum weight of 110 pounds.
Exclusion
- Smoking, a terminal illness, any known chronic illness, rheumatoid arthritis, heart, kidney, liver or gastrointestinal disease requiring treatment, antifolate medications, metformin use.
- More than 2 drinks a day.
- Pregnant women have different metabolism when compared to other adults hence they will not be included in the study.
- Non-English speaking subjects will be excluded since the study involves a computer based diet history questionnaire in English. The budget for this project does not include the cost of an interpreter.
Key Trial Info
Start Date :
February 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2015
Estimated Enrollment :
117 Patients enrolled
Trial Details
Trial ID
NCT03319979
Start Date
February 1 2013
End Date
March 1 2015
Last Update
October 24 2017
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