Status:
COMPLETED
Serum, Dietary and Supplemental Vitamin D's Association With Cognitive Decline
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Cognitive Decline
Cognitive Impairment
Eligibility:
All Genders
30-64 years
Brief Summary
Serum 25(OH)D, dietary and supplemental vitamin D were shown to influence cognitive outcomes in large epidemiological studies. Sex/age-specific and race-specific associations of vitamin D status and i...
Detailed Description
INTRODUCTION Cognitive impairment, a principal cause for functional disability among the elderly, can lead to dementing illness over time mainly in the forms of Alzheimer's Disease (AD) and vascular d...
Eligibility Criteria
Inclusion
- HANDLS initially recruited 3,720 participants (Phase I, visit 1). Given that only Phase II had in-depth data including biochemical indices and cognitive performance measures, 25(OH)D was available for 1,981 participants at baseline. The corresponding sample size for dietary and supplemental vitamin D were N=2,177 and N=2,159, respectively. Complete and reliable cognitive tests at each visit varied in sample size as well. Further, the final analytic sample was determined based on exposure and covariate non-missingness at baseline and outcome non-missingness at either visit. The final analytic sizes ranged between N=1,231 and N=1,803 with k=1.5-1.9 observation/participant.
Exclusion
- HANDLS participants with missing data on cognitive test score on both visits and/or missing data on exposure and covariates included in the mixed-effects regression models.
Key Trial Info
Start Date :
August 18 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 7 2013
Estimated Enrollment :
3720 Patients enrolled
Trial Details
Trial ID
NCT03320109
Start Date
August 18 2004
End Date
July 7 2013
Last Update
October 25 2017
Active Locations (1)
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1
Biomedical Research Center, NIA/NIH/IRP
Baltimore, Maryland, United States, 21224