Status:
UNKNOWN
Multiple Breath Washout, a Clinimetric Dataset
Lead Sponsor:
Imperial College London
Conditions:
Cystic Fibrosis
Primary Ciliary Dyskinesia
Eligibility:
All Genders
2+ years
Brief Summary
Monitoring patients with chronic, inflammatory airways disease particularly in the early stages is hampered by the relative insensitivity of current outcome measures to detect subtle changes. Multiple...
Detailed Description
Lung Clearance Index (LCI) has been shown to be more sensitive and perhaps more applicable in early stages of lung disease when compared to currently utilised physiological outcome measures, and yet i...
Eligibility Criteria
Inclusion
- Inclusion criteria
- For patients with the following respiratory disease, diagnosis confirmed by:
- CF: diagnosed by standard criteria
- PCD: diagnosed by ciliary beat frequency measurement, ciliary beat pattern analysis or electron microscopy of ciliary ultrastructure, or genetics
- Non-CF bronchiectasis: CT diagnosis of bronchiectasis and not fulfilling diagnostic criteria for CF or PCD
- Asthma: as diagnosed by standard diagnostic criteria of British Thoracic Society/Scottish Intercollegiate Guideline Network (BTS/SIGN) guidelines.
- Persistent bacterial bronchitis defined as a wet cough present for \>1 month, usually with bronchoscopic evidence of chronic infection, that resolves with appropriate antibiotic therapy
- Sleep Disordered Breathing.
- For healthy volunteers, these will be colleagues and staff contacts (including children) at a participating centre i.e. Royal Brompton Hospital, or will be siblings of patients.
- Written informed consent (assent from children of appropriate age) obtained.
- Exclusion criteria
- Positive culture (within the last year of / receiving treatment for Mycobaterium tuberculosis or abscessus (due to cross-infection concerns).
- Pregnant or breastfeeding.
- Inability to understand or cooperate with the test(s).
- Inability to give informed consent, or withdrawal of informed consent.
Exclusion
Key Trial Info
Start Date :
May 5 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2024
Estimated Enrollment :
530 Patients enrolled
Trial Details
Trial ID
NCT03320382
Start Date
May 5 2017
End Date
March 1 2024
Last Update
May 6 2022
Active Locations (1)
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1
Royal Brompton Hospital
London, United Kingdom, sw36lr